用99mTc标记抗体对结直肠癌进行放射免疫闪烁显像。

Radioimmunoscintigraphy of colorectal carcinomas with 99mTc-labelled antibodies.

作者信息

Artiko Vera, Petrović Milorad, Sobić-Saranović Dragana, Antić Andrija, Koljević-Marković Ana, Krajnović-Jaksić Emilija, Saranović Djordjije, Petrović Nebojsa, Stojković Mirjana, Durutović Darija, Zuvela Marinko, Radovanović-Bobić Anica, Galun Danijel, Petrasinović Zorica, Pavlović Smiljana, Krivokapić Zoran, Obradović Vladimir

机构信息

Center for Nuclear Medicine, Clinical Center of Serbia, School of Medicine, University of Belgrade, Serbia.

出版信息

Hepatogastroenterology. 2011 Mar-Apr;58(106):347-51.

PMID:21661394

Abstract

BACKGROUND/AIMS: The aim of the study was the evaluation of the clinical validity of immunoscintigraphy with 99mTc labeled antibodies for the detection of metastases and recurrences of colorectal carcinomas.

METHODOLOGY

We examined 17 patients with colorectal carcinomas. Scintigraphy was performed with anti-CEA MoAb 99mTc-BW 431/26.

RESULTS

Recurrences of carcinomas were detected and confirmed by surgery in 6 patients, recurrences with liver metastasis in 5 patients, and only liver metastases in 3 patients. Planar immunoscintigraphy was positive in 5/8 patients with liver metastases and 8/11 patients with recurrences, whereas in 1/8 liver metastases and 3/11 recurrences were detected only by tomography. In two patients with metastases in the abdominal lymph nodes immunoscintigraphic findings both on planar scintigraphy and tomoscintigraphy were false negative.

CONCLUSIONS

Immunoscintigraphy with 99mTc labeled antibodies can be useful in the diagnosis of recurrences and metastases of colorectal carcinoma, viability assessment after radiotherapy and in the choice of the adequate surgical treatment.

摘要

背景/目的：本研究旨在评估99mTc标记抗体免疫闪烁显像在检测结直肠癌转移和复发方面的临床有效性。

方法

我们检查了17例结直肠癌患者。使用抗CEA单克隆抗体99mTc-BW 431/26进行闪烁显像。

结果

6例患者经手术检测并证实有癌复发，5例患者有复发伴肝转移，3例患者仅有肝转移。平面免疫闪烁显像在8例肝转移患者中的5例以及11例复发患者中的8例呈阳性，而在8例肝转移患者中的1例以及11例复发患者中的3例仅通过断层扫描检测到。在2例腹部淋巴结转移患者中，平面闪烁显像和断层闪烁显像的免疫闪烁显像结果均为假阴性。