Laboratoire de Chimie, CNRS, École Normale Supérieure de Lyon, 46 Allée d'Italie, F-69364 Lyon, France.
Org Lett. 2011 Jul 15;13(14):3706-9. doi: 10.1021/ol201355t. Epub 2011 Jun 10.
Hemicryptophanes are host molecules with many applications as supramolecular catalysts or in ion selective recognition. A very convenient and efficient modular approach for the synthesis of hemicryptophane-tren (tren, tris(2-aminoethyl)-amine) derivatives has been developed. For instance, hemicryptophane 1 was synthesized at the gram scale in four steps from vanillyl alcohol compared to the previous seven-step procedure. The size, shape, and functionalities of the molecular cavity were also easily modified.
手性穴醚是一类具有多种用途的主体分子，可用作超分子催化剂或用于离子选择性识别。我们开发了一种非常方便有效的模块化方法来合成穴醚-三乙烯四胺（tren，三（2-氨基乙基）胺）衍生物。例如，与之前的七步反应相比，我们可以从香草醇出发，通过四步反应以克级规模制备穴醚 1。此外，分子空腔的大小、形状和功能也很容易进行修饰。
