Pavone F, Populin R, Castellano C, Kreil G, Melchiorri P
Institute of Psychobiology and Psychopharmacology, National Research Council, Rome, Italy.
Peptides. 1990 May-Jun;11(3):591-4. doi: 10.1016/0196-9781(90)90063-b.
Deltorphin, a heptapeptide that selectively binds to delta receptors, was intracerebroventricularly administered to mice belonging to the strains C57BL/6 and DBA/2 immediately after training in a one-trial inhibitory avoidance task. The retention performance of both strains was improved by the peptide administration, with DBA mice being more sensitive to this effect. The results show different effects of delta and mu receptor agonists on memory consolidation and of strain differences in number and/or distribution of delta opioid receptors in the brain.
强啡肽是一种选择性结合δ受体的七肽，在单次试验抑制性回避任务训练后，立即对C57BL/6和DBA/2品系的小鼠进行脑室内注射。肽给药后，两个品系的记忆保持能力均得到改善，其中DBA小鼠对这种效应更为敏感。结果显示，δ和μ受体激动剂对记忆巩固有不同影响，且脑内δ阿片受体的数量和/或分布存在品系差异。
