Wang Y, Li T
Department of Chemistry, Box 1822-B, Vanderbilt University, Nashville, Tennessee 37235.
Anal Chem. 1999 Oct 1;71(19):4178-82. doi: 10.1021/ac9905017.
A method to screen parallel combinatorial libraries for chiral selectors is described. Crucial elements to such an approach are the efficient syntheses of potential chiral selectors on synthesis resins and the rapid screening of selectors attached to these resins with circular dichroism measurement. The method does not require any immobilization of the analyte and could complement the mixture combinatorial library method developed earlier in this laboratory. The feasibility of this parallel library screening procedure is demonstrated with a model study of the chiral HPLC resolution of (1-naphthyl)leucine ester (1) using a 16-member small library.
本文描述了一种筛选用于手性选择剂的平行组合文库的方法。这种方法的关键要素是在合成树脂上高效合成潜在的手性选择剂，以及通过圆二色性测量快速筛选连接在这些树脂上的选择剂。该方法不需要对分析物进行任何固定，并且可以补充本实验室早期开发的混合组合文库方法。通过使用一个包含16个成员的小型文库对手性HPLC拆分(1-萘基)亮氨酸酯(1)进行模型研究，证明了这种平行文库筛选程序的可行性。
