Rusinov V S, Grindel' O M, Bragina N N, Sharova E V, Barkalaia D B, Korshunov A G, Shchekut'ev G A
Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 Mar-Apr;40(2):218-29.
"Locked-in" state differs from the known states characterized by the motor activity blockade, preservation of conscience of speech contact, despite the fact that connection with outer world during this state is limited only by vertical movements of eyes and eyelids in response to speech signals. Three "locked-in" men were studied at different stages of development of this state. Spectral-coherent analysis of the EEG was conducted. The most typical for the developed state of the "locked-in" man is a uniform change of the intercentral EEG relations. In the motor areas of the cortex alpha-activity and its links are not formed (coherence in alpha-range is zero) while high and low frequencies are coherent. In the visual areas, in contrast, the alpha-rhythm is coherent. Distinct interhemispheric asymmetry of coherent connections appears. In the right hemisphere a decrease of coherence level is sharp and even, in the left one--in occipito-temporal parts the level remains close to norm, while in the frontal parts of the cortex it decreases.
“闭锁”状态不同于以运动活动受阻为特征的已知状态,尽管在此状态下与外部世界的联系仅通过眼睛和眼睑对言语信号的垂直运动来限制,但言语交流的意识得以保留。对处于该状态不同发展阶段的三名“闭锁”患者进行了研究。对脑电图进行了频谱相干分析。“闭锁”患者发展状态最典型的特征是中央间脑电图关系的均匀变化。在皮质的运动区域,α活动及其联系未形成(α范围内的相干性为零),而高频和低频是相干的。相比之下,在视觉区域,α节律是相干的。出现了明显的半球间相干连接不对称。在右半球,相干水平急剧且均匀下降,在左半球,枕颞部的水平仍接近正常,而在皮质的额叶部分则下降。