University of Surrey, Guildford, Surrey GU2 7XH, UK.
Mol Cell Endocrinol. 2012 Feb 5;349(1):45-50. doi: 10.1016/j.mce.2011.05.008. Epub 2011 Jun 1.
Emerging links between circadian rhythms and metabolism promise much for the understanding of metabolic physiology and pathophysiology, in which white adipose tissue (WAT) plays a prominent role. Many WAT endocrine molecules, termed adipokines, display rhythmic plasma concentration. Moreover, similar to most other tissues, WAT exhibits widespread 24-h variation in gene expression, with approximately 20% of the murine adipose transcriptome estimated to undergo daily variation. A major limitation to human chronobiology research is the availability of physiologically defined peripheral tissues. To date most analyses of in vivo human peripheral clocks has been limited to blood leucocytes. However, subcutaneous adipose tissue represents a novel opportunity to study peripheral molecular rhythms that are of clearly defined metabolic relevance. This review summarises basic concepts of circadian and metabolic physiology before then comparing alternative protocols used to analyse the rhythmic properties of human adipose tissue.
昼夜节律与代谢之间新出现的联系有望增进我们对代谢生理学和病理生理学的理解，其中白色脂肪组织（WAT）起着突出的作用。许多 WAT 内分泌分子被称为脂肪因子，它们的血浆浓度呈节律性变化。此外，与大多数其他组织一样，WAT 的基因表达也存在广泛的 24 小时变化，据估计，大约 20%的鼠类脂肪转录组会发生日常变化。人体生物钟研究的一个主要限制是生理定义的周围组织的可用性。迄今为止，大多数对体内人类外周时钟的分析仅限于血液白细胞。然而，皮下脂肪组织为研究与代谢明显相关的外周分子节律提供了一个新的机会。在比较分析人类脂肪组织节律特性的替代方案之前，本文首先总结了昼夜节律和代谢生理学的基本概念。
