Lewis A E
Int J Dermatol. 1979 Jan-Feb;18(1):17-22. doi: 10.1111/j.1365-4362.1979.tb01904.x.
The glucagonoma syndrome is another of those systemic disorders in which skin manifestations provide a clue to the diagnosis. The patient will most often be a middle-aged woman who has the characteristic, indolent skin lesions in the face of diabetes mellitus and additional features to suggest an occult carcinoma. Marked elevation of the levels of plasma glucagon should confirm the suspicion cure of the skin lesions follows cure of the tumor. Two lines of speculation seem promising. Either the initial event is an overproduction of glucagon and all other observations follow. Or the syndrome is another of the polyendocrine disorders. Cases are still too few to resolve either the pathophysiology, prognosis, or even to guess at the true frequency of the syndrome.
胰高血糖素瘤综合征是另一种全身性疾病，其皮肤表现为诊断提供了线索。患者通常为中年女性，患有特征性的、进展缓慢的皮肤病变，同时伴有糖尿病及其他提示隐匿性癌的特征。血浆胰高血糖素水平显著升高应可证实诊断，肿瘤治愈后皮肤病变也随之治愈。目前有两种推测似乎很有前景。要么最初的事件是胰高血糖素分泌过多，随后出现所有其他症状。要么该综合征是多内分泌腺疾病中的一种。目前病例仍然太少，无法解决其病理生理学、预后问题，甚至无法猜测该综合征的实际发病率。
