Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan, ROC.
Microbes Infect. 2011 Oct;13(11):888-94. doi: 10.1016/j.micinf.2011.05.008. Epub 2011 May 30.
Autophagy, that is directly triggered by invaded pathogens and indirectly triggered by IFN-γ, acts as a defense by mediating intracellular microbial recognition and clearance. In addition, autophagy contributes to inflammation by facilitating an IFN-γ response and signal transduction. For immune escape, downregulated autophagy may be a strategy used by microbes.
自噬，既可以被入侵病原体直接触发，也可以被 IFN-γ 间接触发，通过介导细胞内微生物识别和清除来发挥防御作用。此外，自噬通过促进 IFN-γ 反应和信号转导来促进炎症。为了免疫逃避，下调的自噬可能是微生物使用的一种策略。
