Department of Neurology, Chang-Gung Memorial Hospital, Keelung branch, Taiwan.
J Neurol Sci. 2011 Sep 15;308(1-2):94-7. doi: 10.1016/j.jns.2011.05.046. Epub 2011 Jun 12.
This study investigated the impact of smoking on the initial severity of acute ischemic stroke and examined its subsequent outcome.
Patient data was collected from the Stroke Registry in the Chang Gung Healthcare System (SRICHS). A total of 2650 patients admitted for acute ischemic stroke from January to December 2009 were included. Baseline characteristics were compared between smokers and non-smokers. Factors affecting the initial severity and the recovery from neurological deficit were examined by logistic regression analysis. The patients were further divided according to stroke mechanism for subgroup analysis.
The total number of smokers and non-smokers was 817 (31.9%) and 1833 (69.1%), respectively. Univariate analysis showed that smokers had lower NIHSS scores on admission than did non-smokers (P<0.001). In subgroup analysis, smokers with small-vessel occlusions frequently had higher NIHSS scores on admission than did non-smokers (P=0.001). However, smokers with cardioembolic stroke had lower NIHSS scores on admission as compared to non-smokers (P=0.024). No subgroup had smoking as a significant factor for neurological recovery during hospitalization.
Smoking correlated with higher NIHSS scores on admission for small-vessel occlusion. Conversely, it was associated with lower NIHSS scores on admission for cardioembolism.
本研究旨在探讨吸烟对急性缺血性脑卒中初始严重程度的影响，并观察其后续转归。
从长庚医疗体系中风注册研究（SRICHS）中收集患者数据。共纳入 2009 年 1 月至 12 月期间因急性缺血性脑卒中入院的 2650 例患者。比较吸烟者和非吸烟者的基线特征。通过 logistic 回归分析检查影响初始严重程度和神经功能缺损恢复的因素。根据中风机制进一步将患者分组进行亚组分析。
吸烟者和非吸烟者的人数分别为 817 例（31.9%）和 1833 例（69.1%）。单因素分析显示，吸烟者入院时 NIHSS 评分低于非吸烟者（P<0.001）。在亚组分析中，小血管闭塞的吸烟者入院时 NIHSS 评分较非吸烟者高（P=0.001）。然而，心源性栓塞性中风的吸烟者入院时 NIHSS 评分较非吸烟者低（P=0.024）。没有亚组将吸烟作为住院期间神经功能恢复的显著因素。
吸烟与小血管闭塞患者入院时较高的 NIHSS 评分相关。相反，它与心源性栓塞患者入院时较低的 NIHSS 评分相关。
