Vanderhaeghen J J, Schiffmann S, Libert F, Vassart G, Dumont J
Laboratoire de Neuropathologie, Hôpitaux Brugmann, Erasme.
Bull Mem Acad R Med Belg. 1990;145(1-2):144-51.
RDC8 (correction of RCD8), a recently cloned new putative member of the G protein-coupled receptor family protein, is exclusively present in the medium-sized neurons of the striatum. This restricted localisation mimics the major striatal dopamine D1 receptor localisation and is of major importance for the understanding of basal ganglia physiology and degenerative diseases pathogeny such as Huntington's and Parkinson's disease. RDC7, another putative G protein-coupled receptor chemically closely related to RDC8 (correction of RCD8), is mainly distributed in pyramidal neurons of the cerebral cortex, the hippocampus and the claustrum, and in the amygdala, and may represent the minor extra-striatal variant of the D1 receptor.
RDC8（RCD8的校正形式）是G蛋白偶联受体家族蛋白中最近克隆出的一个新的假定成员，仅存在于纹状体的中型神经元中。这种局限的定位类似于主要的纹状体多巴胺D1受体定位，对于理解基底神经节生理学以及亨廷顿氏病和帕金森氏病等退行性疾病的发病机制至关重要。RDC7是另一种与RDC8（RCD8的校正形式）化学关系密切的假定G蛋白偶联受体，主要分布在大脑皮层、海马体和屏状核的锥体神经元以及杏仁核中，可能代表D1受体的次要纹状体外变体。
