Schiffmann S N, Libert F, Vassart G, Dumont J E, Vanderhaeghen J J
Laboratory of Neuropathology and Neuropeptide Research, Faculty of Medicine, Université Libre de Bruxelles, Belgium.
Brain Res. 1990 Jun 11;519(1-2):333-7. doi: 10.1016/0006-8993(90)90097-u.
RDC8, a recently cloned new putative member of the G protein-coupled receptor family, is exclusively present in the medium-sized neurons of the dorsal and ventral striatum in the rat and dog brains. The existence of a striatum-restricted putative G protein-coupled receptor is of major importance for the understanding of basal ganglia physiology and degenerative diseases pathogeny such as Huntington's and Parkinson's disease. This striatal restricted localization mimics the major striatal dopamine D1 receptor localization. RDC7, another putative G protein-coupled receptor presenting a close sequence similarity with RDC8, is mainly distributed in the cerebral cortex, the amygdala, the hippocampus and the claustrum. This localization is also compatible with that expected from a subtype of dopamine D1 receptors.
RDC8是最近克隆出的G蛋白偶联受体家族的一个新的假定成员，仅存在于大鼠和犬脑背侧和腹侧纹状体的中型神经元中。一种纹状体限制性假定G蛋白偶联受体的存在对于理解基底神经节生理学以及亨廷顿病和帕金森病等退行性疾病的发病机制至关重要。这种纹状体限制性定位类似于主要的纹状体多巴胺D1受体定位。RDC7是另一种与RDC8序列相似性很高的假定G蛋白偶联受体，主要分布在大脑皮层、杏仁核、海马体和屏状核。这种定位也与多巴胺D1受体亚型预期的定位相符。
