双氢麦角毒碱对β受体激动剂活性的影响。
Effect of dihydroergotoxine on activities of beta-receptor stimulators.
作者信息
Kitamura S, Ishihara Y, Sasaki K, Shimizu T, Harasawa M
出版信息
Arzneimittelforschung. 1977;27(10):1959-61.
The effect of dihydroergotoxine (DET), an alpha-receptor blocker, on the bronchodilating effect of various beta-receptor stimulators was examined using the isolated guinea-pig tracheal smooth muscle. Relaxation of isolated guinea-pig tracheal smooth muscle with isoproterenol hydrochloride, salbutamol hemisulfate and clorprenaline hydrochloride, was markedly increased by continous infusion of DET. This result may suggest that DET, an alpha-receptor blocker, can be used together with bronchodilators such as beta-receptor stimulator for the treatment of various chronic obstructive pulmonary diseases.
使用离体豚鼠气管平滑肌，研究了α受体阻滞剂双氢麦角毒碱（DET）对各种β受体激动剂支气管舒张作用的影响。持续输注DET可显著增强盐酸异丙肾上腺素、硫酸沙丁胺醇和盐酸氯丙那林对离体豚鼠气管平滑肌的舒张作用。这一结果可能表明，α受体阻滞剂DET可与支气管扩张剂如β受体激动剂联合使用，用于治疗各种慢性阻塞性肺疾病。
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