Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.
J Agric Food Chem. 2011 Jul 27;59(14):7734-42. doi: 10.1021/jf2013716. Epub 2011 Jun 21.
Osteoporosis is a major skeletal disease associated with loss of estrogen in postmenopausal women. In this study, Lactobacillus paracasei subsp. paracasei NTU 101 (NTU 101F) and Lactobacillus plantarum NTU 102 (NTU 102F) were used as starters to ferment soy skim milk. This was then used as a nutritional supplement for 8 weeks to ovariectomized (OVX) mice. This study reveals that soy skim milk fermented with lactobacilli can increase the contents of aglycone isoflavones, soluble calcium, and vitamin D(3). The trabecular bone volumes and trabecular number of the distal femur in mice fed NTU 101F increased by a factor of 1.48 and 1.74 compared with the OVX group. The bone network density and thickness of the distal metaphyseal trabecular in mice fed NTU 101F and Fosamax was significantly greater than that of OVX mice. These results suggest that fermented soy skim milk can attenuate bone loss in OVX mice and lower the risk of osteoporosis.
骨质疏松症是一种与绝经后妇女雌激素缺乏相关的主要骨骼疾病。在这项研究中，副干酪乳杆菌亚种副干酪乳杆菌 NTU 101（NTU 101F）和植物乳杆菌 NTU 102（NTU 102F）被用作发酵大豆脱脂乳的起始物。然后，将其用作去卵巢（OVX）小鼠的营养补充剂 8 周。本研究表明，用乳酸菌发酵的大豆脱脂乳可以增加糖苷异黄酮、可溶性钙和维生素 D（3）的含量。与 OVX 组相比，喂食 NTU 101F 的小鼠的远端股骨小梁体积和小梁数量增加了 1.48 倍和 1.74 倍。喂食 NTU 101F 和福善美（Fosamax）的小鼠的远端干骺端骨小梁的骨网络密度和厚度明显大于 OVX 小鼠。这些结果表明，发酵大豆脱脂乳可以减轻 OVX 小鼠的骨质流失，降低骨质疏松症的风险。
