Department of Dermatology, University of Montpellier I, Saint-Eloi Hospital, France.
Am J Clin Dermatol. 2011 Aug 1;12(4):233-45. doi: 10.2165/11588900-000000000-00000.
Drug-induced acne is a specific subset of acne that usually has some specific features, namely a monomorphic pattern, an unusual location of the lesions beyond the seborrheic areas, an unusual age of onset, a resistance to conventional acne therapy and, of course, the notion of a recent drug introduction. Many drugs can be responsible for such a clinical pattern. Corticosteroids, neuropsychotherapeutic drugs, antituberculosis drugs, and immunomodulating molecules are the more classical drugs associated with induced acne. Recently, new drugs, mainly targeted therapy in the field of oncology, such as epidermal growth factor receptor inhibitors, have been associated with an increased frequency of this adverse effect. Disruption of the culprit drug is rarely mandatory in cases of drug-induced acne. Close cooperation between the dermatologist and medical staff in charge of the patient is an important challenge to achieve optimal management of the initial disease.
药物诱导性痤疮是痤疮的一个特定亚类，通常具有一些特定特征，即单一形态、皮损位置超出皮脂溢区、发病年龄异常、对常规痤疮治疗有抵抗力，当然还有近期引入药物的概念。许多药物都可能导致这种临床模式。皮质类固醇、神经精神治疗药物、抗结核药物和免疫调节分子是与诱导性痤疮相关的更经典药物。最近，新的药物，主要是肿瘤学领域的靶向治疗药物，如表皮生长因子受体抑制剂，与这种不良反应的发生频率增加有关。在药物诱导性痤疮的情况下，很少需要停用致病药物。皮肤科医生与负责患者的医务人员之间的密切合作是实现初始疾病最佳管理的重要挑战。
