Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea.
Immunopharmacol Immunotoxicol. 2012 Feb;34(1):135-42. doi: 10.3109/08923973.2011.587128. Epub 2011 Jun 13.
Allergy is characterized by the overreaction of the immune system. Pyeongwee-San is a traditional Korean medicine which has been used for the treatment of the allergic disorder but the mechanism of action is not clear.
To investigate the effect of Pyeongwee-San extract (KMP6) and its component, hesperidin (HES) in the allergic rhinitis (AR) animal model.
We sensitized mice on 1, 5, and 14 days by intraperitoneal injections of 100 μg ovalbumin (OVA) emulsified in 20 mg of aluminum hydroxide and we challenged mice with 1.5 mg OVA. Mice received KMP6 and HES before the intranasal OVA challenge for 10 days.
The number of nose rubs after the OVA challenge in the OVA-sensitized mice was significantly higher than that in the OVA-unsensitized mice. The increased number of nose rub was inhibited by the oral administration of KMP6 or HES. The increased levels of IgE and histamine level in serum of the OVA-sensitized mice were reduced by KMP6 or HES administration. The level of interferon-γ was enhanced while the level of IL-4 was reduced on the spleen tissue of the KMP6 or HES-administered AR mice. Inflammatory proteins level was reduced by KMP6 or HES administration in the nasal mucosa tissue of the OVA-sensitized mice. In the KMP6 or HES-administered mice, mast cells and eosinophils infiltration increased by OVA-sensitization was decreased.
These results indicate that KMP6 and HES ameliorate the allergic inflammatory reactions such as AR.
过敏是由免疫系统过度反应引起的。萍蔚散是一种传统的韩国药物，已被用于治疗过敏疾病，但作用机制尚不清楚。
研究萍蔚散提取物（KMP6）及其成分橙皮苷（HES）在过敏性鼻炎（AR）动物模型中的作用。
我们通过腹腔注射 100μg 卵清蛋白（OVA）乳化在 20mg 氢氧化铝中来致敏小鼠，在第 1、5 和 14 天，并通过 1.5mg OVA 来挑战小鼠。在鼻内 OVA 挑战前，小鼠接受 KMP6 和 HES 治疗 10 天。
OVA 致敏小鼠在 OVA 挑战后的鼻擦次数明显高于未致敏小鼠。口服 KMP6 或 HES 可抑制鼻擦次数的增加。OVA 致敏小鼠血清中 IgE 和组胺水平的升高被 KMP6 或 HES 给药所抑制。KMP6 或 HES 给药的 AR 小鼠脾组织中干扰素-γ水平升高，IL-4 水平降低。KMP6 或 HES 给药可降低 OVA 致敏小鼠鼻黏膜组织中炎症蛋白的水平。在 KMP6 或 HES 给药的小鼠中，OVA 致敏引起的肥大细胞和嗜酸性粒细胞浸润增加减少。
这些结果表明 KMP6 和 HES 可改善 AR 等过敏性炎症反应。
