平胃散提取物（KMP6）：一种新的抗过敏作用。

Pyeongwee-San extract (KMP6): a new anti-allergic effect.

机构信息

Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea.

出版信息

J Pharm Pharmacol. 2012 Feb;64(2):308-16. doi: 10.1111/j.2042-7158.2011.01405.x. Epub 2011 Nov 18.

DOI:10.1111/j.2042-7158.2011.01405.x

PMID:22221108

Abstract

OBJECTIVES

The prevalence of allergic diseases is increasing due to rapid industrialization and changes in lifestyle. Pyeongwee-San (KMP6) is a traditional Korean medicine that has been used as a basic prescription for digestive disorders. This study investigated the efficacy of KMP6 and its component hesperidin on experimental allergic models.

METHODS

The anti-allergic effect of KMP6 was studied against a compound 48/80-induced systemic anaphylactic reaction and the ear swelling response. In addition, a human mast cell line (HMC-1) was used to analyze the activity of histidine decarboxylase. Passive cutaneous anaphylaxis (PCA) from immunoglobulin E (IgE) was used.

KEY FINDINGS

KMP6 and hesperidin inhibited the compound 48/80-induced systemic anaphylactic reaction and the ear swelling response as well as histamine release, intracellular calcium levels and tryptase release from rat peritoneal mast cells. KMP6 inhibited histidine decarboxylase activity in stimulated HMC-1 cells and macrophages. In addition, KMP6 inhibited the PCA reaction induced by IgE as well as the levels of IgE, interleukin (IL)-4, IL-5, IL-6 and IL-13 in serum from mice.

CONCLUSIONS

These results suggest that KMP6 may exert an anti-allergic effect through not only the inhibition of mast cell degranulation but also the inhibition of histamine synthesis.

摘要

目的

由于工业化和生活方式的快速变化，过敏疾病的患病率正在增加。便卜散（KMP6）是一种传统的韩国药物，一直被用作消化系统疾病的基本处方。本研究调查了 KMP6 及其成分橙皮苷对实验性过敏模型的疗效。

方法

研究了 KMP6 对复合 48/80 诱导的全身性过敏反应和耳部肿胀反应的抗过敏作用。此外，还使用人肥大细胞系（HMC-1）分析组氨酸脱羧酶的活性。被动皮肤过敏（PCA）来自免疫球蛋白 E（IgE）。

主要发现

KMP6 和橙皮苷抑制了复合 48/80 诱导的全身性过敏反应和耳部肿胀反应以及组胺释放、大鼠腹腔肥大细胞内钙水平和胰蛋白酶释放。 KMP6 抑制了刺激的 HMC-1 细胞和巨噬细胞中的组氨酸脱羧酶活性。此外，KMP6 抑制了 IgE 诱导的 PCA 反应以及小鼠血清中 IgE、白细胞介素（IL）-4、IL-5、IL-6 和 IL-13 的水平。