Department of Pediatrics and Neurology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Epilepsia. 2011 Sep;52(9):e106-8. doi: 10.1111/j.1528-1167.2011.03124.x. Epub 2011 Jun 10.
We report the case of a child who presented at 3 months of age with complex partial seizures, a linear facial nevus, and magnetic resonance imaging (MRI) showing delayed myelination and thickened cortex in the left temporal, parietal, and occipital regions. A repeat 3Tesla MRI scan with and without contrast at 6 months again showed cortical dysplasia of the left hemisphere. No other abnormalities were seen. A third scan at 3 years 6 months showed a 2.5 cm, round, hyperintense lesion on both T(2) and T(1) sequences. The lesion and surrounding dysplastic cortex were resected. Palmini grade IIA dysplasia and a ganglioglioma were diagnosed. These findings suggest that cellular components of cortical dysplasias have oncogenic potential.
我们报告了一例 3 个月大的患儿，其表现为复杂部分性发作、线性面部痣和磁共振成像（MRI）显示左侧颞叶、顶叶和枕叶的髓鞘形成延迟和皮质增厚。6 个月时再次进行 3Tesla MRI 扫描，显示左侧大脑半球皮质发育不良，未见其他异常。3 岁 6 个月时的第三次扫描显示在 T(2)和 T(1)序列上均有一个 2.5 厘米的圆形高信号病变。病变和周围的发育不良皮质被切除。诊断为 Palmini Ⅱ A 级发育不良和神经节细胞瘤。这些发现表明皮质发育不良的细胞成分具有致癌潜能。
