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细胞质和转移线粒体核糖体蛋白基因表达在陆生植物中的同步与 Telobox 基序富集有关。

Synchronization of cytoplasmic and transferred mitochondrial ribosomal protein gene expression in land plants is linked to Telo-box motif enrichment.

机构信息

Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

出版信息

BMC Evol Biol. 2011 Jun 13;11:161. doi: 10.1186/1471-2148-11-161.

DOI:10.1186/1471-2148-11-161
PMID:21668973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3212954/
Abstract

BACKGROUND

Chloroplasts and mitochondria evolved from the endosymbionts of once free-living eubacteria, and they transferred most of their genes to the host nuclear genome during evolution. The mechanisms used by plants to coordinate the expression of such transferred genes, as well as other genes in the host nuclear genome, are still poorly understood.

RESULTS

In this paper, we use nuclear-encoded chloroplast (cpRPGs), as well as mitochondrial (mtRPGs) and cytoplasmic (euRPGs) ribosomal protein genes to study the coordination of gene expression between organelles and the host. Results show that the mtRPGs, but not the cpRPGs, exhibit strongly synchronized expression with euRPGs in all investigated land plants and that this phenomenon is linked to the presence of a telo-box DNA motif in the promoter regions of mtRPGs and euRPGs. This motif is also enriched in the promoter regions of genes involved in DNA replication. Sequence analysis further indicates that mtRPGs, in contrast to cpRPGs, acquired telo-box from the host nuclear genome.

CONCLUSIONS

Based on our results, we propose a model of plant nuclear genome evolution where coordination of activities in mitochondria and chloroplast and other cellular functions, including cell cycle, might have served as a strong selection pressure for the differential acquisition of telo-box between mtRPGs and cpRPGs. This research also highlights the significance of physiological needs in shaping transcriptional regulatory evolution.

摘要

背景

叶绿体和线粒体是由曾经自由生活的真细菌的内共生体进化而来的，在进化过程中，它们将大部分基因转移到了宿主核基因组中。植物用来协调这些转移基因以及宿主核基因组中其他基因表达的机制仍知之甚少。

结果

在本文中，我们使用核编码的叶绿体（cpRPGs）以及线粒体（mtRPGs）和细胞质（euRPGs）核糖体蛋白基因来研究细胞器与宿主之间基因表达的协调。结果表明，在所有研究的陆生植物中，mtRPGs 而非 cpRPGs 与 euRPGs 表现出强烈的同步表达，并且这种现象与 mtRPGs 和 euRPGs 启动子区域中存在端粒盒 DNA 基序有关。该基序在参与 DNA 复制的基因启动子区域中也很丰富。序列分析进一步表明，与 cpRPGs 不同，mtRPGs 从宿主核基因组中获得了端粒盒。

结论

基于我们的结果，我们提出了一个植物核基因组进化模型，其中线粒体和叶绿体的活动以及其他细胞功能（包括细胞周期）的协调可能是 mtRPGs 和 cpRPGs 之间端粒盒差异获得的强大选择压力。这项研究还强调了生理需求在塑造转录调控进化方面的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1afe/3212954/d877c5c30d6e/1471-2148-11-161-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1afe/3212954/656f5c65fef9/1471-2148-11-161-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1afe/3212954/3d5a73518675/1471-2148-11-161-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1afe/3212954/8750bba5ffbf/1471-2148-11-161-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1afe/3212954/f892b1d2e5f4/1471-2148-11-161-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1afe/3212954/d877c5c30d6e/1471-2148-11-161-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1afe/3212954/656f5c65fef9/1471-2148-11-161-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1afe/3212954/3d5a73518675/1471-2148-11-161-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1afe/3212954/8750bba5ffbf/1471-2148-11-161-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1afe/3212954/f892b1d2e5f4/1471-2148-11-161-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1afe/3212954/d877c5c30d6e/1471-2148-11-161-5.jpg

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