Dermatological Research Group of the Hungarian Academy of Sciences, Szeged, Hungary.
Hum Immunol. 2011 Sep;72(9):766-73. doi: 10.1016/j.humimm.2011.05.012. Epub 2011 May 24.
Acne is one of the most common dermatologic diseases in the developed regions of the world, affecting a large percentage of the population. Despite the great improvement in the number and quality of studies of the molecular etiology of this disease in the past 3 decades, the detailed molecular pathogenesis and the cause of the large individual variations in severity of skin symptoms remain unknown. The roles of genetic inheritance and special genetic susceptibility and protective factors have been suggested for over 100 years, but their identification and determination started only in the 1990s. To date, only a small number of genetic polymorphisms affecting the expression and/or function of a handful of genes have been investigated. This review surveys the major findings of the classic and molecular genetic studies that have been conducted in this field, draws conclusions, and indicates how the available data help our current understanding of the pathogenesis of this common skin disease.
痤疮是世界发达地区最常见的皮肤病之一，影响了很大一部分人群。尽管在过去的 30 年中，对这种疾病的分子病因学进行了大量的研究，并且研究的数量和质量都有所提高，但皮肤症状严重程度的详细分子发病机制和个体差异的原因仍不清楚。遗传和特殊的遗传易感性和保护因素的作用已被提出 100 多年，但直到 20 世纪 90 年代才开始对其进行鉴定和确定。迄今为止，仅对少数影响少数基因表达和/或功能的遗传多态性进行了研究。本文综述了该领域进行的经典和分子遗传学研究的主要发现，得出结论，并指出现有数据如何帮助我们当前对这种常见皮肤病发病机制的理解。
