Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.
Int J Cancer. 2018 Apr 15;142(8):1580-1585. doi: 10.1002/ijc.31192. Epub 2017 Dec 14.
Accumulating evidence suggest that Propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population-based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (n = 243,187). Test information along with health data including medical diagnoses at time of conscription was available through the Swedish Military Conscription Register and the National Patient Register. The cohort was followed through linkages to the Swedish Cancer Register to identify the occurrence of prostate cancer until December 31, 2009. We used Cox regression to calculate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between acne in adolescence and prostate cancer risk. A total of 1,633 men were diagnosed with prostate cancer during a median follow-up of 36.7 years. A diagnosis of acne was associated with a statistically significant increased risk for prostate cancer (adjusted HR: 1.43 95%; CI: 1.06-1.92), particularly for advanced stage disease (HR: 2.37 95%; CI 1.19-4.73). A diagnosis of acne classified as severe conferred a sixfold increased risk of prostate cancer (HR: 5.70 95% CI 1.42-22.85). Data from this large prospective population-based cohort add new evidence supporting a role of P. acnes infection in prostate cancer.
越来越多的证据表明痤疮丙酸杆菌可能在前列腺癌的发生中起作用，但到目前为止，数据有限且尚无定论。因此，这项基于人群的队列研究旨在检验青春期后期是否存在寻常痤疮是否与日后前列腺癌的风险增加有关。我们确定了一个出生于 1952 年至 1956 年之间的瑞典年轻男性的大型队列，他们在 18 岁左右接受了强制性兵役评估（n=243187）。通过瑞典兵役登记处和国家患者登记处，可以获得测试信息以及入伍时的健康数据，包括医疗诊断。通过与瑞典癌症登记处的链接对队列进行了随访，以确定截至 2009 年 12 月 31 日的前列腺癌的发生情况。我们使用 Cox 回归计算了青春期痤疮与前列腺癌风险之间的关联的调整后的危害比（HR）和 95％置信区间（95％CI）。在中位随访 36.7 年期间，共有 1633 名男性被诊断出患有前列腺癌。痤疮的诊断与前列腺癌风险呈统计学显著相关（调整后的 HR：1.43 95％；CI：1.06-1.92），特别是对于晚期疾病（HR：2.37 95％；CI 1.19-4.73）。严重程度的痤疮诊断使前列腺癌的风险增加了六倍（HR：5.70 95％CI 1.42-22.85）。这项来自大型前瞻性基于人群的队列研究的数据提供了新的证据，支持痤疮丙酸杆菌感染在前列腺癌中的作用。
