肿瘤内注射自体淋巴细胞和人淋巴母细胞干扰素后胶质母细胞瘤的组织学变化。
Histological changes in glioblastoma after intratumoral injection of autologous lymphocytes and human lymphoblastoid interferon.
作者信息
Vaquero J, Coca S, Oya S, Martínez R, Regidor C, Barbolla L, Salazar F G, Ramiro J
机构信息
Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
出版信息
Neurosurgery. 1990 Aug;27(2):235-9. doi: 10.1097/00006123-199008000-00011.
Seven glioblastomas were studied between 1 and 6 months after intratumoral injection of autologous lymphocytes and human lymphoblastoid interferon. Morphological study showed a great number of lymphocytes within the tumor tissue, and interactions between lymphocytes and glioblastoma cells, suggesting a killing phenomenon. These data support the potential usefulness of adoptive immunotherapy in patients with glioblastoma by means of intratumoral administration of activated lymphoid cells.
对7例胶质母细胞瘤患者进行了研究，观察在肿瘤内注射自体淋巴细胞和人淋巴母细胞样干扰素后1至6个月内的情况。形态学研究显示肿瘤组织内有大量淋巴细胞，且淋巴细胞与胶质母细胞瘤细胞之间存在相互作用，提示有杀伤现象。这些数据支持了通过肿瘤内注射活化淋巴细胞对胶质母细胞瘤患者进行过继性免疫治疗的潜在有效性。
Zotero 插件