Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, Japan.
Cancer Lett. 2011 Oct 1;309(1):95-103. doi: 10.1016/j.canlet.2011.05.021. Epub 2011 Jun 12.
We analyzed hepatocellular carcinoma (HCC) with progenitor cell features using hepatic stem/progenitor cell marker neural cell adhesion molecule (NCAM). Approximately 8.3% of the operated HCC cases expressed NCAM, and 22.3% of the HCC patients had soluble NCAM levels >1000ng/ml (the "highly soluble" NCAM group). Soluble NCAM status was a significant independent factor predictive of long-term survival in patients with HCC, and high levels of soluble NCAM were significantly related to intrahepatic metastasis. The 140-kDa NCAM isoform was specifically detected in the "highly soluble" NCAM group of HCC patients andits related signals are potential drug targets for NCAM+ HCC.
我们使用肝干细胞/祖细胞标志物神经细胞黏附分子（NCAM）分析了具有祖细胞特征的肝细胞癌（HCC）。约 8.3%的手术 HCC 病例表达 NCAM，22.3%的 HCC 患者可溶性 NCAM 水平>1000ng/ml（“高可溶性”NCAM 组）。可溶性 NCAM 状态是 HCC 患者长期生存的显著独立预测因素，高水平的可溶性 NCAM与肝内转移显著相关。140kDa 的 NCAM 同工型特异性检测到 HCC 患者的“高可溶性”NCAM 组中，其相关信号是 NCAM+HCC 的潜在药物靶点。
