Kostić M M, Zivković R V, Rapoport S M
Institute of Physiology, Faculty of Medicine, University S. Marković, Kragujevac, Yugoslavia.
Biomed Biochim Acta. 1990;49(2-3):S178-82.
Significant reduction of total and coupled respiration as well as an increase of uncoupled respiration characterize the maturation of rat reticulocytes. ATP declines by 45%, whereas ADP increases by 70% and the ATP/ADP ratio decreases from 7.6 to 3.3. At the same time the oxygen-delivery capacity of red blood cells increases by 37% due to an increase of 2.3-BPG level. In the youngest reticulocytes the basic level of cAMP is 2-fold higher, whereas the maximal (-)-isoproterenol-induced accumulation of cAMP is 8-fold higher than in the fraction of most mature reticulocytes. Evidence for the presence of functionally active glucagon-receptors in reticulocytes is presented, with maturational inactivation/disappearance of R2-glucagon receptors.
大鼠网织红细胞成熟的特征是总呼吸和偶联呼吸显著降低以及解偶联呼吸增加。ATP下降45%，而ADP增加70%，ATP/ADP比值从7.6降至3.3。同时，由于2,3-二磷酸甘油酸（2,3-BPG）水平升高，红细胞的氧输送能力增加37%。在最年轻的网织红细胞中，cAMP的基础水平高2倍，而最大的（-）-异丙肾上腺素诱导的cAMP积累比最成熟网织红细胞部分高8倍。文中提供了网织红细胞中存在功能活跃的胰高血糖素受体的证据，同时存在R2-胰高血糖素受体的成熟失活/消失。
