Department of Internal Medicine I, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-cho, Yufu, Oita 879-5593, Japan.
Mod Rheumatol. 2012 Feb;22(1):137-41. doi: 10.1007/s10165-011-0477-9. Epub 2011 Jun 14.
We report a 16-year-old female case of intractable adult-onset Still's disease accompanied by macrophage activation syndrome, who went into full remission after switching from infliximab to etanercept. Although the disease promptly relapsed when etanercept was discontinued, she again responded fully upon the reintroduction of etanercept. Furthermore, the effect of etanercept was apparently enhanced by combining it with a sufficient dose of methotrexate. This combination therapy should be considered as one of treatment options for the disease.
我们报告了一例 16 岁女性难治性成人斯蒂尔病伴巨噬细胞活化综合征病例，该患者在从英夫利昔单抗转换为依那西普后达到完全缓解。尽管停用依那西普后疾病迅速复发，但再次重新使用依那西普后她又完全缓解。此外，依那西普联合甲氨蝶呤足够剂量时效果明显增强。这种联合治疗应被视为该疾病的治疗选择之一。
