Nagy I, Makara G B, Garamvölgyi V, Bajusz S, Széll E, Rappay G
Heim Pál Pediatric Hospital, Hungarian Academy of Sciences, Budapest.
Biochem Pharmacol. 1990 Aug 15;40(4):887-92. doi: 10.1016/0006-2952(90)90331-e.
A number of oligopeptides, protected at their N termini and possessing an aldehyde residue at their C terminal amino acids, are able to inhibit 45Ca2+ influx into anterior pituitary cells grown in monolayer culture and depolarized with high extracellular potassium concentration. In addition, the same oligopeptides interfere with hormone release, especially with that produced by lactotrophs. Our findings imply that oligopeptides may represent a new class of calcium channel ligands, and the pituitary cells are sensitive targets for them.
一些在其N末端被保护且在其C末端氨基酸处具有醛残基的寡肽，能够抑制45Ca2+流入单层培养并被高细胞外钾浓度去极化的垂体前叶细胞。此外，相同的寡肽会干扰激素释放，尤其是由催乳细胞产生的激素释放。我们的研究结果表明，寡肽可能代表一类新的钙通道配体，并且垂体细胞是它们的敏感靶点。
