Rappay G, Makara G B, Bajusz S, Nagy I
Life Sci. 1985 Feb 11;36(6):549-55. doi: 10.1016/0024-3205(85)90636-8.
Proteinase inhibitors were tested for their ability to inhibit prolactin (PRL) and growth hormone (GH) release by cultured anterior pituitary cells of the rat. Inhibitors of microbial origin (chymostatin, elastatinal, leupeptin) had either no or a moderate effect on hormone release while some tripeptide aldehydes, especially those with lysine at their C terminus, inhibited markedly PRL and to a lesser extent GH release. Boc-DPhe-Phe-lysinal was the most effective on lactotrophs inhibiting PRL release more than 50% at 10(-4) M. The site(s) of action of tripeptide aldehydes remain to be elucidated.
对蛋白酶抑制剂抑制大鼠培养的垂体前叶细胞释放催乳素（PRL）和生长激素（GH）的能力进行了测试。微生物来源的抑制剂（抑肽酶、弹性蛋白酶抑制剂、亮抑酶肽）对激素释放要么没有影响，要么只有中等程度的影响，而一些三肽醛，尤其是C末端带有赖氨酸的那些，能显著抑制PRL释放，对GH释放的抑制作用较小。Boc-DPhe-Phe-赖氨醛对催乳细胞最有效，在10⁻⁴ M时抑制PRL释放超过50%。三肽醛的作用位点尚待阐明。
