用于医学和农业的猪的基因修饰。
Genetic modifications of pigs for medicine and agriculture.
机构信息
National Swine Resource and Research Center, University of Missouri, Columbia, Missouri 65211, USA.
出版信息
Mol Reprod Dev. 2011 Oct-Nov;78(10-11):879-91. doi: 10.1002/mrd.21333. Epub 2011 Jun 10.
Abstract
Genetically modified swine hold great promise in the fields of agriculture and medicine. Currently, these swine are being used to optimize production of quality meat, to improve our understanding of the biology of disease resistance, and to reduced waste. In the field of biomedicine, swine are anatomically and physiologically analogous to humans. Alterations of key swine genes in disease pathways provide model animals to improve our understanding of the causes and potential treatments of many human genetic disorders. The completed sequencing of the swine genome will significantly enhance the specificity of genetic modifications, and allow for more accurate representations of human disease based on syntenic genes between the two species. Improvements in both methods of gene alteration and efficiency of model animal production are key to enabling routine use of these swine models in medicine and agriculture.
摘要
转基因猪在农业和医学领域具有巨大的应用潜力。目前，这些猪被用于优化优质肉类的生产，以增进我们对疾病抗性生物学的理解，并减少浪费。在生物医学领域，猪在解剖学和生理学上与人类相似。改变疾病途径中的关键猪基因可提供模型动物，以增进我们对许多人类遗传疾病的病因和潜在治疗方法的理解。猪基因组的完成测序将极大地提高遗传修饰的特异性，并允许基于两个物种之间的同线性基因，更准确地模拟人类疾病。基因修饰方法的改进和模型动物生产效率的提高是使这些猪模型在医学和农业中得到常规应用的关键。
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