Diabetes and Obesity Laboratory, Institute for Biomedical Research August Pi i Sunyer (IDIBAPS) and Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain.
Arch Physiol Biochem. 2011 Jul;117(3):177-87. doi: 10.3109/13813455.2011.584538.
Over the last decades, substantial progress has been made in defining the molecular events and relevant tissues controlling insulin action and the potential defects that lead to insulin resistance and later on Type 2 diabetes mellitus (T2DM). Mitochondrial dysfunction has been postulated as a common mechanism implicated in the development of insulin resistance and T2DM aetiology. Since then there has been growing interest in this area of research and many studies have addressed whether mitochondrial function/dysfunction is implicated in the progression of T2DM or if it is just a consequence. Mitochondria are adjusted to the specific needs of the tissue and to the environmental interactions or pathophysiological state that it encounters. This review offers a current state of the subject in a tissue specific approach. We will focus our attention on skeletal muscle, liver, and white adipose tissue as the main insulin sensitive organs. Hypothalamic mitochondrial function will be also discussed.
在过去的几十年中，在定义控制胰岛素作用的分子事件和相关组织方面取得了重大进展，以及导致胰岛素抵抗和随后的 2 型糖尿病（T2DM）的潜在缺陷。线粒体功能障碍被认为是导致胰岛素抵抗和 T2DM 发病机制的共同机制。从那时起，人们对这一研究领域产生了越来越大的兴趣，许多研究都探讨了线粒体功能/障碍是否与 T2DM 的进展有关，或者它是否只是一个结果。线粒体适应组织的特定需求以及它所遇到的环境相互作用或病理生理状态。本综述以组织特异性方法提供了该主题的最新状态。我们将重点关注骨骼肌、肝脏和白色脂肪组织作为主要的胰岛素敏感器官。还将讨论下丘脑的线粒体功能。
