Blois Shauna L, Dickie Erica, Kruth Stephen A, Allen Dana G
Department of Clinical Studies and Ontario Veterinary College Teaching Hospital, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
J Am Vet Med Assoc. 2011 Jun 15;238(12):1616-21. doi: 10.2460/javma.238.12.1616.
To characterize a population of dogs from a tertiary care center with 2 or more endocrine disorders, including the specific disorders and time intervals between diagnosis of each disorder.
Retrospective case series.
35 dogs with 2 or more endocrine disorders.
Medical records were reviewed, and the following was recorded: clinical signs, physical examination findings, and the results of CBC, serum biochemical analysis, urinalysis, aerobic bacterial culture of urine samples, endocrine testing, diagnostic imaging, and necropsy.
35 dogs with more than 1 endocrine disorder were identified. Seventy-seven percent (27/35) of the dogs were male, and the mean age at the time of diagnosis of the first endocrinopathy was 7.9 years. Miniature Schnauzer was the most common breed. Twenty-eight of 35 (80%) dogs had 2 disorders; 7 (20%) had 3 disorders. The most common combinations of disorders included diabetes mellitus and hyperadrenocorticism in 57.1 % (20/35) of dogs; hypoadrenocorticism and hypothyroidism in 22.9% (8/35) of dogs; and diabetes mellitus and hypothyroidism in 28.6% (10/35) of dogs. A mean of 14.5 months elapsed between diagnosis of the first and second endocrine disorders, whereas there was a mean of 31.1 months between diagnosis of the first and third endocrine disorders.
Results suggested that the occurrence of multiple endocrine disorders was uncommon in dogs. The most common combinations of endocrine disorders in this population of dogs were diabetes mellitus and hyperadrenocorticism, followed by hypoadrenocorticism and hypothyroidism.
对一家三级护理中心患有两种或更多种内分泌疾病的犬类群体进行特征描述，包括具体疾病以及每种疾病诊断之间的时间间隔。
回顾性病例系列研究。
35只患有两种或更多种内分泌疾病的犬。
查阅病历，并记录以下内容：临床症状、体格检查结果、血常规、血清生化分析、尿液分析、尿液样本需氧菌培养、内分泌检测、诊断性影像学检查和尸检结果。
确定了35只患有不止一种内分泌疾病的犬。77%（27/35）的犬为雄性，首次诊断内分泌病时的平均年龄为7.9岁。迷你雪纳瑞是最常见的品种。35只犬中有28只（80%）患有两种疾病；7只（20%）患有三种疾病。最常见的疾病组合包括：57.1%（20/35）的犬患有糖尿病和肾上腺皮质功能亢进；22.9%（8/35）的犬患有肾上腺皮质功能减退和甲状腺功能减退；28.6%（10/35）的犬患有糖尿病和甲状腺功能减退。首次和第二次内分泌疾病诊断之间平均间隔14.5个月，而首次和第三次内分泌疾病诊断之间平均间隔31.1个月。
结果表明，多种内分泌疾病在犬中并不常见。该犬类群体中最常见的内分泌疾病组合是糖尿病和肾上腺皮质功能亢进，其次是肾上腺皮质功能减退和甲状腺功能减退。
