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Curr Top Med Chem. 2011;11(17):2227-36. doi: 10.2174/156802611796904915.
TRPA1 is a member of a superfamily of non-selective cation channels that is known to be involved in multiple physiological functions. TRPA1 is activated by a broad spectrum of chemical irritants and endogenous inflammatory compounds. An emerging role for TRPA1 in mediating pain and inflammation raises the possibility that compounds targeting TRPA1 might have significant therapeutic potential. This review discusses the broad classes of molecules that are known to act as agonists and antagonists of TRPA1 towards the aim of providing an overview of the structure and activity of TRPA1 modulators.
TRPA1 是一种非选择性阳离子通道超家族的成员，已知其参与多种生理功能。TRPA1 可被多种化学刺激物和内源性炎症化合物激活。TRPA1 在介导疼痛和炎症中的新作用表明，靶向 TRPA1 的化合物可能具有重要的治疗潜力。本文综述了已知作用于 TRPA1 的激动剂和拮抗剂的分子类别，旨在概述 TRPA1 调节剂的结构和活性。
