Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, China.
J Membr Biol. 2023 Dec;256(4-6):301-316. doi: 10.1007/s00232-023-00277-x. Epub 2023 Apr 11.
For a long time, the physiological activity of TRP ion channels and the response to various stimuli have been the focus of attention, and the physiological functions mediated by ion channels have subtle links with the occurrence of various diseases. Our group has been engaged in the study of ion channels. In recent years, the report rate of TRPA1, the only member of the TRPA subfamily in the newly described TRP channel, has been very high. TRPA1 channels are not only abundantly expressed in peptidergic nociceptors but are also found in many nonneuronal cell types and tissues, and through the regulation of Ca influx, various neuropeptides and signaling pathways are involved in the regulation of nerves, respiration, circulation, and various diseases and inflammation throughout the body. In this review, we mainly summarize the effects of TRPA1 on various systems in the body, which not only allows us to have a more systematic and comprehensive understanding of TRPA1 but also facilitates more in-depth research on it in the future.
很长一段时间以来，TRP 离子通道的生理活性及其对各种刺激的反应一直是研究的焦点，而离子通道介导的生理功能与各种疾病的发生有着微妙的联系。我们的研究小组一直致力于离子通道的研究。近年来，新发现的 TRP 通道中唯一的 TRPA1 亚家族成员的报告率非常高。TRPA1 通道不仅在肽能伤害感受器中大量表达，而且在许多非神经元细胞类型和组织中也有表达，通过调节 Ca2+内流，参与调节全身的神经、呼吸、循环和各种疾病和炎症的各种神经肽和信号通路。在这篇综述中，我们主要总结了 TRPA1 对机体各系统的影响，这不仅使我们对 TRPA1 有了更系统、更全面的认识，也为今后对其进行更深入的研究提供了便利。
