Altaras M M, Jaffe R, Cohen I, Gruber A, Yanai-Inbar I, Bernheim J
Department of Obstetrics and Gynecology A, Sapir Medical Center, Kfar Saba, Israel.
Gynecol Oncol. 1990 Aug;38(2):273-7. doi: 10.1016/0090-8258(90)90054-o.
Two cases of endometrial sarcoma that developed many years after exposure to unopposed exogenous and endogenous estrogens, with no previous pelvic irradiation, are described. The literature is reviewed and the possible effect of prolonged unopposed estrogen stimulation is suggested as an etiologic factor in such extremely rare conditions. These cases add additional support to the assumption that prolonged and excessive endogenous or exogenous unopposed estrogen stimulation of the uterus may increase the risk of endometrial sarcoma.
本文描述了两例子宫内膜肉瘤病例，患者在暴露于无对抗的外源性和内源性雌激素多年后发病，且既往无盆腔放疗史。本文对相关文献进行了综述，并指出在这种极为罕见的情况下，长期无对抗的雌激素刺激可能是一个病因。这些病例进一步支持了这样一种假设，即子宫长期受到内源性或外源性无对抗雌激素的过度刺激可能会增加患子宫内膜肉瘤的风险。
