Sinclair D G, Winfield C R
Army Chest Unit, Cambridge Military Hospital, Aldershot, Hants.
J R Army Med Corps. 1990 Jun;136(2):105-6. doi: 10.1136/jramc-136-02-09.
A randomized double blind cross over trial to compare nedocromil sodium and sodium cromoglycate with placebo in the prevention of exercise induced asthma was conducted. Twenty asthmatics received nedocromil sodium, sodium cromoglycate or placebo via metered dose inhalers on successive days 30 minutes before exercise in a randomized order. Nedocromil sodium and sodium cromoglycate gave sufficient protection (P less than 0.05) compared to placebo as assessed by the reduction in the maximum percentage fall in the forced expiratory volume in 1 second (FEV1). The protective effect of nedocromil sodium and sodium cromoglycate varied in individuals.
进行了一项随机双盲交叉试验，以比较奈多罗米钠、色甘酸钠与安慰剂预防运动诱发性哮喘的效果。20名哮喘患者通过定量吸入器，在运动前30分钟，按随机顺序连续数天接受奈多罗米钠、色甘酸钠或安慰剂治疗。根据一秒用力呼气量（FEV1）最大下降百分比的降低情况评估，与安慰剂相比，奈多罗米钠和色甘酸钠提供了足够的保护（P<0.05）。奈多罗米钠和色甘酸钠的保护作用在个体间有所不同。
