de Benedictis F M, Tuteri G, Bertotto A, Bruni L, Vaccaro R
Clinica Pediatrica, University of Perugia, Italy.
J Allergy Clin Immunol. 1994 Oct;94(4):684-8. doi: 10.1016/0091-6749(94)90175-9.
Seventeen children with asthma were studied in a double-blind, crossover, placebo-controlled study designed to compare the efficacy of cromolyn sodium with that of nedocromil sodium in preventing exercise-induced asthma. All drugs were delivered through a metered-dose inhaler (cromolyn sodium, 10 mg; nedocromil sodium, 4 mg; placebo, two puffs). Nedocromil sodium and cromolyn sodium provided significant, comparable protection from exercise-induced asthma, and both drugs were better than placebo. We conclude that nedocromil sodium and cromolyn sodium administered by a pressurized aerosol provide equal protection against exercise-induced asthma in children.
在一项双盲、交叉、安慰剂对照研究中，对17名哮喘儿童进行了研究，该研究旨在比较色甘酸钠与奈多罗米钠预防运动诱发性哮喘的疗效。所有药物均通过定量吸入器给药（色甘酸钠10毫克；奈多罗米钠4毫克；安慰剂，两喷）。奈多罗米钠和色甘酸钠对运动诱发性哮喘均提供了显著且相当的保护作用，且两种药物均优于安慰剂。我们得出结论，通过压力气雾剂给药的奈多罗米钠和色甘酸钠对儿童运动诱发性哮喘提供同等的保护作用。
