[The effects of dopamine and/or dibutyryl cyclic AMP on renal dysfunction induced by IPPV with PEEP in dogs].

We investigated the effects of dopamine (Dop) and/or dibutyryl cyclic AMP (DBcAMP) on renal dysfunction induced by IPPV with PEEP in 32 anesthetized dogs. Blood pressure, pulse rate, creatinine clearance and free water clearance were not significantly altered during the experiment. On the other hand, cardiac index (CI), renal blood flow (RBF), urine output and fractional sodium excretion (FENa) were all decreased significantly by PEEP. Dop and/or DBcAMP improved urine output and FENa irrespective of decreased CI and RBF by PEEP. The increase of urine output could be attributed to the decrease of the water reabsorption in the proximal renal tubule by the drugs. The simultaneous infusion of Dop and DBcAMP was more effective for renal dysfunction caused by PEEP than individual administration of each drug.