Im J G, Han M C, Yu E J, Han J K, Park J M, Kim C W, Seo J W, Yoon Y, Lee J D, Lee K S
Department of Radiology, College of Medicine, Seoul National University, Korea.
Radiology. 1990 Sep;176(3):749-53. doi: 10.1148/radiology.176.3.2167502.
The authors reviewed computed tomographic (CT) scans of 12 patients with lobar bronchioloalveolar carcinoma. Seven patients had consolidation of the entire lobe, and five patients had segmental consolidation. After contrast material was administered intravenously, the consolidated lung typically appeared on the scan as an area of homogeneous low attenuation, within which were enhanced branching pulmonary vessels (the CT angiogram sign). To evaluate the specificity of this sign in the discrimination of bronchioloalveolar carcinoma, CT scans of 26 patients who had lobar consolidation from other diseases were randomly mixed with the CT scans of 11 patients with bronchioloalveolar carcinoma. Two independent observers who were unfamiliar with the cases classified 10 and nine of the 11 patients with bronchioloalveolar carcinoma, respectively, as positive for bronchioloalveolar carcinoma by applying the CT angiogram sign, and classified as negative 25 and 23 of the 26 patients without bronchioloalveolar carcinoma, respectively, for an overall specificity of 92.3%. The angiogram sign appeared on the CT scan because of the low-attenuating consolidation, which was caused by the production of mucin or other fluid and the intact bronchovascular framework within the tumor.
作者回顾了12例肺叶细支气管肺泡癌患者的计算机断层扫描（CT）图像。7例患者整个肺叶出现实变，5例患者出现节段性实变。静脉注射造影剂后，实变的肺组织在扫描图像上通常表现为均匀的低密度区，其中可见强化的分支状肺血管（CT血管造影征）。为评估该征象在鉴别细支气管肺泡癌中的特异性，将26例因其他疾病导致肺叶实变患者的CT扫描图像与11例细支气管肺泡癌患者的CT扫描图像随机混合。两位不熟悉病例的独立观察者，通过应用CT血管造影征，分别将11例细支气管肺泡癌患者中的10例和9例判定为细支气管肺泡癌阳性，将26例非细支气管肺泡癌患者中的25例和23例判定为阴性，总体特异性为92.3%。CT扫描上出现血管造影征是由于肿瘤内产生黏液或其他液体以及完整的支气管血管结构导致的低密度实变。
