Fujimoto Kiminori
Department of Radiology, Kurume University School of Medicine and Center for Diagnostic Imaging, Kurume University Hospital, 67 Asahi-machi, Kurume, Fukuoka, 830-0011 Japan.
Cancer Imaging. 2008 Mar 3;8(1):36-44. doi: 10.1102/1470-7330.2008.0009.
Evaluation of solitary pulmonary nodules (SPNs) poses a challenge to radiologists. Chest computed tomography (CT) is considered the standard technique for assessing morphologic findings and intrathoracic spread of an SPN. Although the clinical role of magnetic resonance imaging (MRI) for SPNs remains limited, considerable experience has been gained with MRI of thoracic diseases. Dynamic MRI and dynamic CT are useful for differentiating between malignant and benign SPNs (especially tuberculomas and hamartomas). Furthermore, dynamic MRI is useful for assessing tumor vascularity, interstitium, and vascular endothelial growth factor expression, and for predicting survival outcome among patients with peripheral pulmonary carcinoma. These advantages make dynamic MRI a promising method and a potential biomarker for characterizing tumor response to anti-angiogenic treatment as well as for predicting survival outcomes after treatment.
孤立性肺结节（SPN）的评估给放射科医生带来了挑战。胸部计算机断层扫描（CT）被认为是评估SPN形态学表现和胸内扩散的标准技术。尽管磁共振成像（MRI）在SPN方面的临床作用仍然有限，但在胸部疾病的MRI方面已经积累了相当多的经验。动态MRI和动态CT有助于鉴别恶性和良性SPN（尤其是结核瘤和错构瘤）。此外，动态MRI有助于评估肿瘤血管、间质和血管内皮生长因子表达，并预测周围型肺癌患者的生存结果。这些优势使动态MRI成为一种有前景的方法和潜在的生物标志物，可用于表征肿瘤对抗血管生成治疗的反应以及预测治疗后的生存结果。
