Departamento de Farmacobiología, Cinvestav-Sede Sur, Calzada de los Tenorios 235, Col. Granjas Coapa, Deleg. Tlalpan, DF México.
J Sex Med. 2012 Apr;9(4):1015-26. doi: 10.1111/j.1743-6109.2011.02339.x. Epub 2011 Jun 15.
Selective serotonin reuptake inhibitors (SSRIs) are antidepressants that cause sexual dysfunction. The SSRI fluoxetine (FLX) appears to particularly affect the ejaculatory response. Ejaculation is regulated both at brain and spinal levels.
To study the acute and chronic effects of FLX on male rat copulatory behavior, trying to distinguish between brain and spinal cord FLX-induced changes on the ejaculatory response.
Sexually experienced male rats were intraperitoneally injected with 5 or 10 mg/kg FLX and tested for sexual behavior during 60 minutes on days 1, 7, and 14 of treatment. After a 2-day drug holiday, the males chronically treated with the high FLX dose were spinalized to record spontaneous and mechanically evoked genital motor patterns of ejaculation (GMPEs). In addition, independent groups were used to evaluate the acute effects of 1, 3, or 10 µg/rat FLX (intravenously) on the GMPE.
Number of ejaculatory series and their parameters; electromyographic recordings of the GMPE in the bulbospongiosus muscles and their parameters.
Acute FLX injection slightly affected sexual behavior display and dose-dependently inhibited the expression of the GMPE. Chronic FLX treatment did not inhibit copulation but produced deficits in the parameters related to ejaculation after the high dose. In these animals, the response capacity of the spinal generator of ejaculation (SGE) as well as the number of discharges in the GMPE was decreased as a result of chronic FLX treatment.
Chronic FLX treatment produces inhibitory effects on male rat copulation, particularly on ejaculation, some of which are exerted directly at the SGE.
选择性 5-羟色胺再摄取抑制剂（SSRIs）是一种会引起性功能障碍的抗抑郁药。SSRIs 类药物氟西汀（FLX）似乎特别影响射精反应。射精受到大脑和脊髓水平的调节。
研究 FLX 对雄性大鼠交配行为的急性和慢性影响，试图区分 FLX 对射精反应的大脑和脊髓诱导变化。
对有性经验的雄性大鼠进行腹腔注射 5 或 10mg/kg 的 FLX，并在治疗的第 1、7 和 14 天的 60 分钟内测试性行为。在停药 2 天后，对接受高剂量 FLX 慢性治疗的雄性大鼠进行脊髓切断术，以记录自发性和机械诱发的射精生殖器运动模式（GMPEs）。此外，还使用独立的组来评估 1、3 或 10µg/大鼠 FLX（静脉内）对 GMPE 的急性影响。
射精系列的数量及其参数；球海绵体肌 GMPE 的肌电图记录及其参数。
急性 FLX 注射轻微影响性行为表现，并呈剂量依赖性抑制 GMPE 的表达。慢性 FLX 治疗不抑制交配，但在高剂量后会导致与射精相关的参数缺陷。在这些动物中，由于慢性 FLX 治疗，射精脊髓发生器（SGE）的反应能力以及 GMPE 中的放电次数减少。
慢性 FLX 治疗对雄性大鼠的交配行为产生抑制作用，特别是对射精行为，其中一些作用直接在 SGE 上发挥。
