Sasaki Y, Imaoka S, Masutani S, Nagano H, Ohashi I, Kameyama M, Fukuda I, Ishikawa O, Ohigashi H, Hiratsuka M
Dept. of Surgery, Center for Adult Diseases, Osaka.
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 2):1661-4.
Chemoembolization using Lipiodol, cisplatin, angiotensin II and Gelfoam (modified sandwich therapy) was carried out for the patients with liver metastasis from colorectal cancer. 1. Ten of 30 patients who underwent hepatic resection received TAE before operation, and the remaining 20 underwent surgery without preoperative TAE. Three-year survival of the former was 66%, and that of the latter was 44% (not significant). 2. Twenty-two patients who were assessed as non-resectable were surgically catheterized into the hepatic artery. Thirteen patients received TAE (totally 38 times) and intra-arterial infusion chemotherapy, and the remaining 9 underwent intra-arterial chemotherapy alone. The 50% survival of the former and the latter was 545 and 285 days, respectively. One year survival of the former was significantly better than that of the latter. 3. Fourteen patients had intrahepatic recurrences after hepatic resections. Eight patients received TAE and the remaining 6 did not. The 50% survival of the former was 615 days and that of the latter was 190 days. For one-year survival, the former was significantly better than the latter. These results suggested that TAE is an effective modality for liver metastasis from colorectal cancer.
对结直肠癌肝转移患者采用碘油、顺铂、血管紧张素 II 和明胶海绵进行化疗栓塞（改良三明治疗法）。1. 30 例行肝切除的患者中，10 例术前接受了肝动脉栓塞化疗（TAE），其余 20 例未接受术前 TAE 直接进行手术。前者的三年生存率为 66%，后者为 44%（无显著差异）。2. 22 例被评估为不可切除的患者通过手术将导管插入肝动脉。13 例患者接受了 TAE（共 38 次）及动脉内灌注化疗，其余 9 例仅接受动脉内化疗。前者和后者的 50%生存率分别为 545 天和 285 天。前者的一年生存率显著高于后者。3. 14 例患者肝切除术后出现肝内复发。8 例接受了 TAE，其余 6 例未接受。前者的 50%生存率为 615 天，后者为 190 天。就一年生存率而言，前者显著高于后者。这些结果表明，TAE 是治疗结直肠癌肝转移的一种有效方式。
