Nakashima K, Iwao Y, Suzuki K, Tada I, Kim Y I, Kobayashi M, Mori K, Takayama F, Takeyama M, Aikawa H
First Dept. of Surgery, Medical College of Oita.
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 2):1731-5.
The efficacy of concentrated CDDP-Lipiodol Emulsion was experimentally and clinically studied in the treatment of nonresectable hepatoma. The commercially available CDDP was ten-fold concentrated into water in oil form. The agent was administered via hepatic artery in 26 patients with nonresectable hepatocellular carcinoma. In vitro and clinical studies strongly suggested a gradual release of the CDDP into the surrounding tissue. In 9 out of 26 patients (34.6%), tumor regression was found. Side effects were minimum; mild nausea and vomiting were observed in only 13 patients. On the basis of our preliminary study, concentrated CDDP-Lipiodol emulsion promises to be a useful agent for the treatment of nonresectable hepatocellular carcinoma.
对浓缩顺铂-碘油乳剂治疗不可切除肝癌的疗效进行了实验和临床研究。将市售顺铂浓缩成10倍的油包水型。经肝动脉将该制剂给予26例不可切除肝细胞癌患者。体外和临床研究有力地提示顺铂可逐渐释放到周围组织中。26例患者中有9例（34.6%）出现肿瘤消退。副作用极小；仅13例患者出现轻度恶心和呕吐。根据我们的初步研究，浓缩顺铂-碘油乳剂有望成为治疗不可切除肝细胞癌的有效药物。
