去神经支配的青蛙肌肉终板区域中循环鸟苷单磷酸增加。

Increased cyclic GMP in the end-plate region of denervated frog muscle.

作者信息

Allen D O, Gardner R M, Yount R A, Ochs S

出版信息

J Neurobiol. 1978 Nov;9(6):445-51. doi: 10.1002/neu.480090604.

Abstract

Denervated frog sartorius muscles showed an approximately 2--3 fold increase of cyclic GMP in their end-plate rich regions which did not appear up to 5 weeks after denervation in the normally end-plate-free pelvic region. No increase in cyclic AMP was seen in these preparations. The results suggest that the increase of cyclic GMP is related to processes specific to the region in which end plates are normally present.

摘要

去神经支配的青蛙缝匠肌在其富含终板的区域中，环磷酸鸟苷（cGMP）增加了约2至3倍，而在正常情况下无终板的骨盆区域，去神经支配后5周内未见这种增加。在这些标本中未观察到环磷酸腺苷（cAMP）增加。结果表明，环磷酸鸟苷的增加与终板正常存在区域的特定过程有关。