Root M J
Colgate-Palmolive Company, Piscatway, New Jersey.
Calcif Tissue Int. 1990 Aug;47(2):112-6. doi: 10.1007/BF02555994.
The induction time for amorphous calcium phosphate (ACP) phase transformation was monitored at pH 7.4 and T = 25 degrees C with [Ca2+]o = [PO4]o = 4.0 X 10(-3) M, as a function of added crystal growth inhibitors Mg2+, Sr2+, Zn2+, pyrophosphate (PP), and tripolyphosphate (TPP). Metal ions increase the induction time for the initiation of the phase change reaction in the order Zn2+ less than Sr2+ less than Mg2+. For polyphosphates it was observed that both PP and TPP are potent inhibitors with TPP more effective than PP as expected. The combination of Mg2+ or Sr2+ and PP or TPP leads to a synergistic delay in the onset of the phase conversion. The greatest inhibition was observed for Mg2+ and TPP. Reaction solutions containing 2.0 X 10(-4) M Mg2+ and 4.0 X 10(-5) M TPP resulted in a 90% increase in the induction time over what would be anticipated from an additive effect from these species.
在pH值为7.4、温度T = 25℃、[Ca2+]o = [PO4]o = 4.0×10(-3)M的条件下，监测了无定形磷酸钙（ACP）相变的诱导时间，该诱导时间是添加的晶体生长抑制剂Mg2+、Sr2+、Zn2+、焦磷酸盐（PP）和三聚磷酸盐（TPP）的函数。金属离子增加相变反应起始诱导时间的顺序为Zn2+ < Sr2+ < Mg2+。对于多磷酸盐，观察到PP和TPP都是有效的抑制剂，正如预期的那样，TPP比PP更有效。Mg2+或Sr2+与PP或TPP的组合导致相变开始出现协同延迟。观察到Mg2+和TPP的抑制作用最大。含有2.0×10(-4)M Mg2+和4.0×10(-5)M TPP的反应溶液的诱导时间比这些物质的加和效应预期的增加了90%。
