Zhou X J
Department of Ultrastructural Pathology, Jinling Hospital, Nanjing.
Zhonghua Bing Li Xue Za Zhi. 1990 Jun;19(2):100-2.
5 cases of pituitary adenomas associated with Cushing's disease or Nelson's syndrome were studied with electron microscopy and immunoelectron microscopy by using protein A--gold complex. Diversified ultrastructure was displayed in these tumors, among which 4 revealed presence of ACTH positive secretory granules. These granules were round or polyhedric in shape, varied in number, size and electronic density. Bundles of microfilaments could be seen in the tumor cells frequently, which were of the highest diagnostic value. There was no significant difference found in ultrastructure and immunocytochemical reaction of adenomas in Cushing's disease and Nelson's syndrome.
对5例与库欣病或尼尔森综合征相关的垂体腺瘤进行了研究，采用蛋白A-金复合物进行电子显微镜和免疫电子显微镜观察。这些肿瘤呈现出多样化的超微结构，其中4例显示存在促肾上腺皮质激素（ACTH）阳性分泌颗粒。这些颗粒呈圆形或多面体形，数量、大小和电子密度各不相同。在肿瘤细胞中经常可见微丝束，其具有最高的诊断价值。库欣病和尼尔森综合征中腺瘤的超微结构和免疫细胞化学反应未发现显著差异。
