Tomlinson B E, Perry R H, Stewart-Wynne E G
J Neurol Neurosurg Psychiatry. 1979 Jan;42(1):82-8. doi: 10.1136/jnnp.42.1.82.
A retrospective survey of 100 patients dying from carcinoma of the lung showed that neurological presentation and central nervous system metastases are more frequently present when the primary carcinoma is situated in the peripheral lung tissue (including lung apex). The high incidence of cases presenting neurologically and the high incidence of single secondary deposits involving the central nervous system from peripheral or apical growths suggest a difference in the mode of spread or other properties of such growths compared with the more common central carcinoma.
对100例死于肺癌的患者进行的回顾性调查显示，当原发性癌位于肺外周组织（包括肺尖）时，神经学表现和中枢神经系统转移更为常见。外周或肺尖生长的肿瘤在神经学上表现出的高发病率以及累及中枢神经系统的单个继发性病灶的高发病率表明，与更常见的中央型癌相比，此类肿瘤的扩散方式或其他特性存在差异。
