Romano A, Kaplinsky C, Frand M, Rotem Y, Stein R, Blumenthal M
J Pediatr Ophthalmol Strabismus. 1978 Jul-Aug;15(4):239-45. doi: 10.3928/0191-3913-19780701-13.
A case of Neonatal Herpes Simlex Virus (RSV) Encephalitis with severe ocular manifestation treated by topical systemic and intrathecal Interferon inducer, Poly IC (Polyriboinosinic acid-Polyribocytidylic acid) is reported. Prior to the administration of Poly IC, no Interferon could be detected neither in blood nor in CSF and vesicular fluid from conjunctiva. Intravenous administration of the drug initiated measurable levels in blood and tears, but not in CSF. However, intrathecal injection induced persistent high levels of Interferon in CSF. Virus clearance from conjunctiva tears and vesicular fluid occurred after three days of topical application of Poly IC. The mechanism of action of Poly IC, the laboratory results and the therapeutic conclusions are discussed in detail. This is the first report of intrathecal administration of Poly IC in a case of HSV Encephalitis.
报告了一例新生儿单纯疱疹病毒（RSV）脑炎伴严重眼部表现，采用局部、全身及鞘内注射干扰素诱导剂聚肌胞苷酸（Poly IC，聚肌苷酸-聚胞苷酸）进行治疗的病例。在给予聚肌胞苷酸之前，在血液、脑脊液以及结膜水疱液中均未检测到干扰素。静脉注射该药物后，血液和泪液中出现了可测量的干扰素水平，但脑脊液中未出现。然而，鞘内注射诱导脑脊液中持续出现高水平的干扰素。在局部应用聚肌胞苷酸三天后，结膜、泪液和水疱液中的病毒得以清除。详细讨论了聚肌胞苷酸的作用机制、实验室结果及治疗结论。这是首例关于在单纯疱疹病毒脑炎病例中鞘内注射聚肌胞苷酸的报告。
