Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, Italy.
Clin Biochem. 2011 Aug;44(12):1015-7. doi: 10.1016/j.clinbiochem.2011.05.027. Epub 2011 Jun 6.
We hypothesized that LOX-1 polymorphism may impact on inflammation and cardiovascular risk by modulating systemic resistin expression.
276 men were randomly selected from a population-based cohort. Metabolic and inflammatory markers were evaluated at baseline and after 6-years follow-up, OLR1 (loxin) IVS4-14 A>G polymorphism was assessed.
Mean plasma resistin and nitrotyrosine values were significantly higher, and TAS was significantly lowered in homozygous for the G allele. The G allele was significantly and directly associated with resistin and nitrotyrosine values.
Enhanced oxidized-LDL uptake by LOX-1 G-allele carriers is associated with increased pro-oxidant status and resistin levels, suggesting a major uptake of ox-LDL by macrophages, smooth muscle cells, and monocytes.
我们假设 LOX-1 多态性可能通过调节系统抵抗素表达来影响炎症和心血管风险。
从基于人群的队列中随机选择 276 名男性。在基线和 6 年随访时评估代谢和炎症标志物，评估 OLR1（lox）IVS4-14 A>G 多态性。
在纯合子中，血浆抵抗素和硝基酪氨酸的平均水平显著升高，TAS 显著降低。G 等位基因与抵抗素和硝基酪氨酸值显著且直接相关。
LOX-1 G 等位基因携带者对氧化 LDL 的摄取增强与促氧化剂状态和抵抗素水平升高有关，提示巨噬细胞、平滑肌细胞和单核细胞对 ox-LDL 的摄取增加。
