Bo S, Gambino R, Pagani A, Guidi S, Gentile L, Cassader M, Pagano G F
Department of Internal Medicine, University of Turin, Turin, Italy.
Int J Obes (Lond). 2005 Nov;29(11):1315-20. doi: 10.1038/sj.ijo.0803037.
Data on the association of resistin levels with markers of insulin resistance are highly contrasting in humans and very few studies about its role in inflammation are available. This study investigates associations between serum resistin levels and markers of insulin resistance, inflammation (C-reactive protein (CRP)) and of oxidative stress (nytrotirosine (NT)).
A randomly collected sample of 300 men from a population-based cohort was analysed, separated into two groups according to body mass index (BMI) and waist values.
Correlations between resistin and BMI, waist, triglyceride, uric acid, fasting glucose, insulin and Homeostasis Model Assessment (HOMA) values were significant in subjects with normal BMI, but not in overweight/obese subjects. In a multiple regression model, after multiple adjustments and exclusion of diabetic patients, only fasting glucose remained significantly associated with resistin levels. Otherwise, resistin is associated to CRP levels in all individuals, after multiple adjustments and exclusion of diabetic patients (in normal BMI beta=0.82; 95% CI 0.21, 1.42; in overweight/obese beta=0.43; 95% CI 0.10, 0.76). In the same model, resistin values are negatively related to NT levels in normal weight individuals (beta=-1.61; 95% CI -0.77-2.45).
Serum resistin is weakly associated with metabolic abnormalities in subjects with normal BMI, while in overweight/obese patients this correlation is not significant, perhaps due to the higher fat content in these subjects. Serum resistin is directly correlated with CRP and inversely to NT. An intriguing hypothesis, which needs to be tested, is that resistin is secreted in response to a chronic low-grade inflammation, and has antioxidant properties.
关于抵抗素水平与胰岛素抵抗标志物之间关联的数据在人类研究中差异很大，且关于其在炎症中作用的研究很少。本研究调查血清抵抗素水平与胰岛素抵抗、炎症（C反应蛋白（CRP））及氧化应激（硝基酪氨酸（NT））标志物之间的关联。
对从基于人群的队列中随机抽取的300名男性样本进行分析，根据体重指数（BMI）和腰围值分为两组。
在BMI正常的受试者中，抵抗素与BMI、腰围、甘油三酯、尿酸、空腹血糖、胰岛素及稳态模型评估（HOMA）值之间存在显著相关性，但在超重/肥胖受试者中无显著相关性。在多元回归模型中，经过多次调整并排除糖尿病患者后，只有空腹血糖仍与抵抗素水平显著相关。此外，在多次调整并排除糖尿病患者后，抵抗素与所有个体的CRP水平相关（BMI正常者β=0.82；95%可信区间0.21，1.42；超重/肥胖者β=0.43；95%可信区间0.10，0.76）。在同一模型中，正常体重个体的抵抗素值与NT水平呈负相关（β=-1.61；95%可信区间-0.77 - 2.45）。
血清抵抗素与BMI正常受试者的代谢异常弱相关，而在超重/肥胖患者中这种相关性不显著，可能是由于这些受试者脂肪含量较高。血清抵抗素与CRP直接相关，与NT呈负相关。一个需要验证的有趣假说是，抵抗素是对慢性低度炎症的反应而分泌，且具有抗氧化特性。
