Department of Dermatology and Venereology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Salata 4, 10000 Zagreb, Croatia.
Clin Dermatol. 2011 Jul-Aug;29(4):377-88. doi: 10.1016/j.clindermatol.2011.01.007.
The histologic picture of intraepidermal and subepidermal autoimmune bullous dermatoses is presented. Histologic changes are described according to the temporal evolution of lesions, with special reference to crucial elements of the histologic differential diagnosis. The diagnosis of autoimmune bullous dermatoses is complex, mostly requiring additional immunofluorescence assays along with histoclinical correlation to detect the antibodies or target antigen by the methods of molecular biology or immunohistochemistry. Additional tests to reach an accurate diagnosis in various autoimmune bullous dermatoses are briefly described, emphasizing the need of proper integration of all clinical and laboratory data. Although frequently inadequately specific, the histologic finding provides a link between clinical findings and target molecular studies in autoimmune bullous dermatoses.
本文呈现了表皮内和表皮下自身免疫性大疱性皮肤病的组织学图像。根据病变的时间演变描述了组织学变化，并特别参考了组织学鉴别诊断的关键要素。自身免疫性大疱性皮肤病的诊断较为复杂，通常需要进行额外的免疫荧光检测，并结合组织临床相关性，通过分子生物学或免疫组织化学方法检测抗体或靶抗原。简要描述了在各种自身免疫性大疱性皮肤病中达到准确诊断所需的其他检测，强调了需要适当整合所有临床和实验室数据。尽管组织学发现通常不够特异，但它在自身免疫性大疱性皮肤病中为临床发现与靶分子研究之间提供了联系。
