Busse E, Baum R P, Hör G, Kornhuber B
Abteilung für Hämatologie und Onkologie, Johann Wolfgang Goethe-Universität, Frankfurt/Main, BRD.
Nuklearmedizin. 1990 Jun;29(3):125-8.
We studied the effect of thyroxine (T4 0.050 mg/kg/d, i.p.), TSH (0.08 U/kg/d, i.p.) and hypothalamic peptide (HF; 1 mg protein/kg/d, i.p.) given alone or in combination, on the growth of murine (NB C-1300) and human (NB Park) neuroblastoma transplanted onto the nude mouse (nu/nu). Both T4 and TSH caused a significant increase (perchlorate a decrease) of the serum T3. Histologically, the T4 treatment was followed by partial tumor necrosis and a marked growth of connective tissue within the tumors; there was no significant change in tumor weight as compared to the control group. Treatment with HF alone or in combination with T4 inhibited in 30% the invasive growth of the neuroblastoma transplants and a fatty degeneration was found in 25% of the human NB-TX after 28 days of treatment. The measurement of the intratumoral content of the cyclic nucleotides showed a significant increase of the cAMP and a decrease of the cGMP. The morphological and biochemical alteration observed under treatment with thyroid hormone or analogues could possibly be applied for therapeutic purposes.
我们研究了单独或联合给予甲状腺素（T4，0.050毫克/千克/天，腹腔注射）、促甲状腺激素（TSH，0.08单位/千克/天，腹腔注射）和下丘脑肽（HF；1毫克蛋白质/千克/天，腹腔注射）对移植到裸鼠（nu/nu）体内的小鼠（NB C-1300）和人（NB Park）神经母细胞瘤生长的影响。T4和TSH均导致血清T3显著升高（高氯酸盐导致降低）。组织学上，T4治疗后肿瘤出现部分坏死，肿瘤内结缔组织显著生长；与对照组相比，肿瘤重量无显著变化。单独使用HF或与T4联合使用可抑制30%的神经母细胞瘤移植瘤的侵袭性生长，治疗28天后，25%的人NB-TX出现脂肪变性。肿瘤内环核苷酸含量的测定显示cAMP显著升高，cGMP降低。甲状腺激素或类似物治疗下观察到的形态学和生化改变可能可用于治疗目的。
