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结构基因组学的成功。

The success of structural genomics.

作者信息

Terwilliger Thomas C

机构信息

Los Alamos National Laboratory, Mail Stop M888, Los Alamos, NM 87545, USA.

出版信息

J Struct Funct Genomics. 2011 Jul;12(2):43-4. doi: 10.1007/s10969-011-9114-2. Epub 2011 Jun 17.

DOI:10.1007/s10969-011-9114-2
PMID:21681528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3123458/
Abstract

The International Conference on Structural Genomics (ICSG 2011, http://sgc.utoronto.ca/ICSG2011/index.php ) [corrected], held in Toronto Canada May 10-14, 2011 was a rich and exciting demonstration of how far structural genomics has come. Structural genomics has now matured into a field that includes both structure and the biology that structure enables. This has allowed targeting based on systematic approaches and on known biological importance and allows biochemical studies to be closely tied to structure determination. The wealth of purified proteins, clones, and chemical probes produced by structural genomics groups will enable a vast amount of follow-on research. The technologies, the structures, and the biology that were described at the meeting were at the cutting edge of science. Structural genomics has become a success.

摘要

2011年5月10日至14日在加拿大多伦多举行的国际结构基因组学会议(ICSG 2011,http://sgc.utoronto.ca/ICSG2011/index.php )[已修正],充分展示了结构基因组学所取得的丰硕成果,令人振奋。结构基因组学如今已发展成为一个既涵盖结构又包含由结构所支撑的生物学内容的领域。这使得基于系统方法和已知生物学重要性进行靶向研究成为可能,并使生化研究与结构测定紧密相连。结构基因组学团队所产生的大量纯化蛋白质、克隆以及化学探针,将推动大量后续研究。会议上所描述的技术、结构和生物学均处于科学前沿。结构基因组学已取得成功。